Effect of Copper on Hemostasis and the Inflammatory Response
- Categories: Corporate News
- Author:Ashley Laderer
- Time of issue:2021/11/19
- Views:
(Summary description)
Effect of Copper on Hemostasis and the Inflammatory Response
(Summary description)
- Categories:Corporate News
- Author:Ashley Laderer
- Time of issue:2021/11/19
- Views:
Effect of Copper on Hemostasis and the Inflammatory Response
Effect of Copper on Hemostasis and the Inflammatory Response
PDGF plays a significant role not only during hemostasis but also during the several stages of wound repair. It stimulates not only the proliferation and migration of fibroblasts and smooth muscle cells but also the migration of inflammatory cells such as neutrophils and macrophages. In vitro studies have provided insight that the cell migration stimulated by PDGF is copper dependent and that copper plays an important role in the first two stages of wound healing. Copper accumulates during the inflammation phase, where it will be used by inflammatory cells such as macrophages.
Effect of Copper on Proliferation
Copper's role in facilitating angiogenesis has been known for some time, but only more recent studies have shed light on the specific copper targets. VEGF is an important growth factor which stimulates angiogenesis, a key part of the proliferation phase. Copper is able to induce VEGF expression in keratinocytes, which is confirmed by enhanced VEGF expression in copper-treated wounds. Furthermore, the release of two polypeptides also involved in angiogenesis, fibroblast growth factor 1 (FGF-1) and interleukin 1α (IL-1α), is upregulated by copper.
Effect of Copper on Remodeling
During remodeling, fibronectin mats are formed to strengthen the scar. Fibronectin stabilization and cell ingrowth are stimulated by low concentrations of copper. Copper also forms complexes with the tripeptide glycyl-l-histidyl-l-lysine (GHK), which upregulate important remodeling proteins such as collagen, elastin, metalloproteinases, VEGF, fibroblast growth factor, and nerve growth factor. Furthermore, cross-linking of collagen and elastin is catalyzed by the copper-dependent enzyme lysyl oxidase (LOX).
(To be continued)
Copy from cmr.asm.org
--------------------------------------------------------------------
清渤美(滨州)科技发展有限公司
Qingbomei (Binzhou) Technology Development Co., Ltd.
Special Recommendation of Anti-bacterial Copper ion infused KN95 Cotton face mask (Efficient, Multifunctional, Washable, Reusable,Breathable, Adjustable, Customizable and Fashionable).
With high BFE (Bacterial Filter Efficiency 99.9%, Filter Efficiency>99%), low breath resistance(Inhalation Resistance 70-80Pa, Exhalation Resistance 60-70Pa) and multifunctional features, this new mask has been certified as meeting the standards of KN95 and FFP2.
(Hope you will find us by searching these keywords: Mask, Facemask, Face mask, Cotton face mask, Antivirus face mask, anti-virus face mask, Washable face mask, Reusable face mask, Antimicrobial face mask, anti-microbial face mask, antibacterial face mask, anti-bacterial face mask, Copper face mask , Copper ion face mask, Copper infused face mask, Copper-infused face mask, Copper ion infused face mask, Copper antibacterial face mask, Copper anti-bacterial face mask, Copper antibacterial face mask, Copper anti-microbial face mask, Copper, cotton mask face mask, Copper infused cotton face mask, Copper-infused cotton face mask and Copper ion infused cotton face masks...)
Qingbomei (Binzhou) Technology Development Co., Ltd
Contact us by Wechat
Copyright © 2020 Qingbomei (Binzhou) Technology Development Co., Ltd All rights reserved. 鲁ICP备2020048408号-1 Powered by:www.300.cn