The effect of Wound healing
- Categories: Corporate News
- Author:Ashley Laderer
- Time of issue:2021/11/19
- Views:
(Summary description)
The effect of Wound healing
(Summary description)
- Categories:Corporate News
- Author:Ashley Laderer
- Time of issue:2021/11/19
- Views:
The effect of Wound healing
Wound healing is a complex cascade of events on a cellular level which comprises four stages: hemostasis, inflammation, proliferation, and remodeling. Hemostasis is dominated by platelets, which release two main factors: platelet-derived growth factor (PDGF) and transforming growth factor beta (TGF-β). Inflammatory cells such as neutrophils, mast cells, macrophages, and T lymphocytes clean the wound from injured and contaminated tissue in the inflammatory phase. Characteristic features of the proliferation phase epithelialization, fibroplasia, and angiogenesis. Epithelialization is stimulated by epidermal growth factor (EGF) and TGF-α, which are produced by macrophages. Angiogenesis is initiated by vascular endothelial cell growth factor (VEGF), basic fibroblast growth factor (bFGF), and TGF-β. During remodeling, matrix proteins such as collagen, proteoglycans, and fibronectin are produced and form tight connections to increase the strength of the scar.
Mechanism of wound healing. Wound healing is a complex cascade characterized by four overlapping phases: bleeding and hemostasis, inflammation, proliferation, and remodeling. At the time of injury, the tissue is disrupted, and the platelets stick together to seal damage to the blood vessel. After this, fibrin strands begin to adhere. Following hemostasis, the neutrophils enter the wound site and begin removing foreign materials, bacteria, and damaged tissue. The inflammatory phase continues with highly phagocytic macrophages that are responsible for removing nonfunctional host cells, bacterium-filled neutrophils, damaged matrix, foreign debris, and any remaining bacteria. Once the wound site is cleaned out, the migrated fibroblasts begin the proliferation phase. The objective of the proliferation phase is for the wound to be “rebuilt” with new granulation tissue, which is comprised of collagen and extracellular matrix and into which a new network of blood vessels develops, a process known as angiogenesis. Epithelial cells finally resurface the wound, a process known as epithelization. During the final remodeling phase, the collagen forms well-organized stable cross-links.
Dysregulation of this complex mechanism will result in fibrosis and chronic ulceration and is associated with increased morbidity and mortality. According to the literature, the function of many factors involved in wound healing is dependent on and modulated by copper ions, and thus, copper is involved in all four stages of wound healing. It is hypothesized that delayed wound healing could partially be explained by depleted copper levels, which in turn reinforces a role for this element as an essential micro-trace nutrient required from diet.
(To be continued)
Copy from cmr.asm.org
--------------------------------------------------------------------
清渤美(滨州)科技发展有限公司
Qingbomei (Binzhou) Technology Development Co., Ltd.
Special Recommendation of Anti-bacterial Copper ion infused KN95 Cotton face mask (Efficient, Multifunctional, Washable, Reusable,Breathable, Adjustable, Customizable and Fashionable).
With high BFE (Bacterial Filter Efficiency 99.9%, Filter Efficiency>99%), low breath resistance(Inhalation Resistance 70-80Pa, Exhalation Resistance 60-70Pa) and multifunctional features, this new mask has been certified as meeting the standards of KN95 and FFP2.
(Hope you will find us by searching these keywords: Mask, Facemask, Face mask, Cotton face mask, Antivirus face mask, anti-virus face mask, Washable face mask, Reusable face mask, Antimicrobial face mask, anti-microbial face mask, antibacterial face mask, anti-bacterial face mask, Copper face mask , Copper ion face mask, Copper infused face mask, Copper-infused face mask, Copper ion infused face mask, Copper antibacterial face mask, Copper anti-bacterial face mask, Copper antibacterial face mask, Copper anti-microbial face mask, Copper, cotton mask face mask, Copper infused cotton face mask, Copper-infused cotton face mask a
Qingbomei (Binzhou) Technology Development Co., Ltd
Contact us by Wechat
![Qingbomei (Binzhou) Technology Development Co., Ltd Qingbomei (Binzhou) Technology Development Co., Ltd](static/picture/weixin_1.jpg)
Copyright © 2020 Qingbomei (Binzhou) Technology Development Co., Ltd All rights reserved. 鲁ICP备2020048408号-1 Powered by:www.300.cn